Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Programmed –1 ribosomal frameshifting (PRF) in cardioviruses is activated by the 2A protein, a multi-functional virulence factor that also inhibits cap-dependent translational initiation. Here we present the X-ray crystal structure of 2A and show that it selectively binds to a pseudoknot-like confor...

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Detalles Bibliográficos
Autores principales: Hill, Chris H., Pekarek, Lukas, Napthine, Sawsan, Kibe, Anuja, Firth, Andrew E., Graham, Stephen C., Caliskan, Neva, Brierley, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660796/
https://www.ncbi.nlm.nih.gov/pubmed/34887415
http://dx.doi.org/10.1038/s41467-021-27400-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660796/
https://www.ncbi.nlm.nih.gov/pubmed/34887415
http://dx.doi.org/10.1038/s41467-021-27400-7

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