RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

The CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored acetylation-induced changes in the composition of the CCR4-NOT complex by purification of the endogenously tagged scaffold subunit NOT1 and...

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Detalles Bibliográficos
Autores principales: Poetz, Fabian, Corbo, Joshua, Levdansky, Yevgen, Spiegelhalter, Alexander, Lindner, Doris, Magg, Vera, Lebedeva, Svetlana, Schweiggert, Jörg, Schott, Johanna, Valkov, Eugene, Stoecklin, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660800/
https://www.ncbi.nlm.nih.gov/pubmed/34887419
http://dx.doi.org/10.1038/s41467-021-27471-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660800/
https://www.ncbi.nlm.nih.gov/pubmed/34887419
http://dx.doi.org/10.1038/s41467-021-27471-6

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