HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas

Myosin heavy chain 9 (MYH9) plays an essential role in human diseases, including multiple cancers; however, little is known about its role in gliomas. In the present study, we revealed that HMGA1 and MYH9 were upregulated in gliomas and their expression correlated with WHO grade, and HMGA1 promoted...

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Detalles Bibliográficos
Autores principales: Que, Tianshi, Zheng, Haojie, Zeng, Yu, Liu, Xinru, Qi, Ge, La, Qingcuo, Liang, Tuo, Li, Zhiyong, Yi, Guozhong, Zhang, Shichao, Li, Junjie, Nie, Jing, Tan, Jian-er, Huang, Guanglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660812/
https://www.ncbi.nlm.nih.gov/pubmed/34887392
http://dx.doi.org/10.1038/s41419-021-04440-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660812/
https://www.ncbi.nlm.nih.gov/pubmed/34887392
http://dx.doi.org/10.1038/s41419-021-04440-x

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