Cargando…

HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas

Myosin heavy chain 9 (MYH9) plays an essential role in human diseases, including multiple cancers; however, little is known about its role in gliomas. In the present study, we revealed that HMGA1 and MYH9 were upregulated in gliomas and their expression correlated with WHO grade, and HMGA1 promoted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Que, Tianshi, Zheng, Haojie, Zeng, Yu, Liu, Xinru, Qi, Ge, La, Qingcuo, Liang, Tuo, Li, Zhiyong, Yi, Guozhong, Zhang, Shichao, Li, Junjie, Nie, Jing, Tan, Jian-er, Huang, Guanglong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660812/ https://www.ncbi.nlm.nih.gov/pubmed/34887392 http://dx.doi.org/10.1038/s41419-021-04440-x

Ejemplares similares

Correction to: HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas
por: Que, Tianshi, et al.
Publicado: (2022)

Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma
por: Lin, Xian, et al.
Publicado: (2020)

Oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin promotes the malignant phenotype of glioma
por: Zeng, Yu, et al.
Publicado: (2021)

NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun
por: Chen, Zigui, et al.
Publicado: (2021)

Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling
por: Wang, Cun, et al.
Publicado: (2016)

The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
por: Meng, Yang, et al.
Publicado: (2021)

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway
por: Chen, Shiyu, et al.
Publicado: (2020)

HMGA1 participates in MHCC97H cell proliferation and invasion through the ILK/Akt/GSK3β signaling pathway
por: Liu, Li, et al.
Publicado: (2017)

Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer
por: Zhu, Yinghui, et al.
Publicado: (2022)

The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3′UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2
por: Wang, Yuan, et al.
Publicado: (2017)

c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability
por: Ciani, Lorenza, et al.
Publicado: (2007)

SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9‐Mediated GSK3β/β‐Catenin Signaling
por: Li, Qing, et al.
Publicado: (2023)

ENKUR recruits FBXW7 to ubiquitinate and degrade MYH9 and further suppress MYH9‐induced deubiquitination of β‐catenin to block gastric cancer metastasis
por: Liu, Jiahao, et al.
Publicado: (2022)

HMGA2 enhances 5-fluorouracil chemoresistance in colorectal cancer via the Dvl2/Wnt pathway
por: Xu, Xi, et al.
Publicado: (2018)

Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway
por: Shao, Hui, et al.
Publicado: (2023)

Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway
por: Ng, Lui, et al.
Publicado: (2018)

TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling
por: Gao, Song, et al.
Publicado: (2022)

The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling
por: Chakraborty, Atanu, et al.
Publicado: (2015)

MYH9 nephropathy
por: Oh, Taehoon, et al.
Publicado: (2015)

GRP75‐mediated upregulation of HMGA1 stimulates stage I lung adenocarcinoma progression by activating JNK/c‐JUN signaling
por: Qiao, Guo‐Bing, et al.
Publicado: (2021)

Novel Reporter Alleles of GSK-3α and GSK-3β
por: Barrell, William B., et al.
Publicado: (2012)

Nonmuscle myosin 2 proteins encoded by Myh9, Myh10, and Myh14 are uniquely distributed in the tubular segments of murine kidney
por: Otterpohl, Karla L., et al.
Publicado: (2017)

Oskar Is Targeted for Degradation by the Sequential Action of Par-1, GSK-3, and the SCF(-Slimb) Ubiquitin Ligase
por: Morais-de-Sá, Eurico, et al.
Publicado: (2013)

Mutations in the tail domain of MYH3 contributes to atrial septal defect
por: Maran, Sathiya, et al.
Publicado: (2020)

Expanding the mutation and phenotype spectrum of MYH3-associated skeletal disorders
por: Zhao, Sen, et al.
Publicado: (2022)

HTLV-3 and HTLV-4 antisense proteins activate JunB-, c-Jun- and JunD-dependent transcription
por: Larocque, Émilie, et al.
Publicado: (2011)

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways
por: Chow, Raymond Kwok Kei, et al.
Publicado: (2016)

Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models()()
por: Ugolkov, Andrey, et al.
Publicado: (2017)

Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development
por: Guo, Shuyu, et al.
Publicado: (2021)

MYH3‐associated distal arthrogryposis zebrafish model is normalized with para‐aminoblebbistatin
por: Whittle, Julia, et al.
Publicado: (2020)

Mutation of the MYH3 gene causes recessive cleft palate in Limousine cattle
por: Vaiman, Anne, et al.
Publicado: (2022)

Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3β
por: Cymerman, Iwona A., et al.
Publicado: (2015)

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
por: Gozdz, Agata, et al.
Publicado: (2017)

Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3β-β-Catenin and XIAP-Survivin Pathways
por: Chang, Yun-Xun, et al.
Publicado: (2020)

GSK-3 in Neurodegenerative Diseases
por: Lei, Peng, et al.
Publicado: (2011)

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
por: Teixeira, Felipe Roberti, et al.
Publicado: (2016)

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis
por: Moore, Samantha F., et al.
Publicado: (2021)

Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
por: Ahn, Kwanghee, et al.
Publicado: (2019)

LncRNA FEZF1-AS1 Modulates Cancer Stem Cell Properties of Human Gastric Cancer Through miR-363-3p/HMGA2
por: Hui, Yuanjian, et al.
Publicado: (2020)

Molecular mechanism by which CDCP1 promotes proneural-mesenchymal transformation in primary glioblastoma
por: Lin, Zhiying, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4vqhua3g3cfp3cl7ahtbpr8n4j