NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation

A functional mitotic spindle is essential for accurate chromosome congression and segregation during cell proliferation; however, the underlying mechanisms of its assembly remain unclear. Here we show that NuMA regulates this assembly process via phase separation regulated by Aurora A. NuMA undergoe...

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Detalles Bibliográficos
Autores principales: Sun, Mengjie, Jia, Mingkang, Ren, He, Yang, Biying, Chi, Wangfei, Xin, Guangwei, Jiang, Qing, Zhang, Chuanmao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660824/
https://www.ncbi.nlm.nih.gov/pubmed/34887424
http://dx.doi.org/10.1038/s41467-021-27528-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660824/
https://www.ncbi.nlm.nih.gov/pubmed/34887424
http://dx.doi.org/10.1038/s41467-021-27528-6

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