Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM

Slowpoke (Slo) potassium channels display extraordinarily high conductance, are synergistically activated by a positive transmembrane potential and high intracellular Ca(2+) concentrations and are important targets for insecticides and antiparasitic drugs. However, it is unknown how these compounds...

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Detalles Bibliográficos
Autores principales: Raisch, Tobias, Brockmann, Andreas, Ebbinghaus-Kintscher, Ulrich, Freigang, Jörg, Gutbrod, Oliver, Kubicek, Jan, Maertens, Barbara, Hofnagel, Oliver, Raunser, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660915/
https://www.ncbi.nlm.nih.gov/pubmed/34887422
http://dx.doi.org/10.1038/s41467-021-27435-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660915/
https://www.ncbi.nlm.nih.gov/pubmed/34887422
http://dx.doi.org/10.1038/s41467-021-27435-w

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