The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice

Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects are persistent challenges. In this study, we investigated...

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Detalles Bibliográficos
Autores principales: Jouvet, Nathalie, Bouyakdan, Khalil, Campbell, Scott A., Baldwin, Cindy, Townsend, Shannon E., Gannon, Maureen A., Poitout, Vincent, Alquier, Thierry, Estall, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660978/
https://www.ncbi.nlm.nih.gov/pubmed/34610983
http://dx.doi.org/10.2337/db21-0147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660978/
https://www.ncbi.nlm.nih.gov/pubmed/34610983
http://dx.doi.org/10.2337/db21-0147

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