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The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects are persistent challenges. In this study, we investigated...
Autores principales: | Jouvet, Nathalie, Bouyakdan, Khalil, Campbell, Scott A., Baldwin, Cindy, Townsend, Shannon E., Gannon, Maureen A., Poitout, Vincent, Alquier, Thierry, Estall, Jennifer L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660978/ https://www.ncbi.nlm.nih.gov/pubmed/34610983 http://dx.doi.org/10.2337/db21-0147 |
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