Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms

Recognition of β-cell antigens by autoreactive T cells is a critical step in the initiation of autoimmune type1 diabetes. A complete protection from diabetes development in NOD mice harboring a point mutation in the insulin B-chain 9–23 epitope points to a dominant role of insulin in diabetogenesis....

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Detalles Bibliográficos
Autores principales: Srivastava, Neetu, Hu, Hao, Vomund, Anthony N., Peterson, Orion J., Baker, Rocky L., Haskins, Kathryn, Teyton, Luc, Wan, Xiaoxiao, Unanue, Emil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660984/
https://www.ncbi.nlm.nih.gov/pubmed/34497137
http://dx.doi.org/10.2337/db21-0513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660984/
https://www.ncbi.nlm.nih.gov/pubmed/34497137
http://dx.doi.org/10.2337/db21-0513

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