Cargando…

Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms

Recognition of β-cell antigens by autoreactive T cells is a critical step in the initiation of autoimmune type1 diabetes. A complete protection from diabetes development in NOD mice harboring a point mutation in the insulin B-chain 9–23 epitope points to a dominant role of insulin in diabetogenesis....

Descripción completa

Detalles Bibliográficos
Autores principales:	Srivastava, Neetu, Hu, Hao, Vomund, Anthony N., Peterson, Orion J., Baker, Rocky L., Haskins, Kathryn, Teyton, Luc, Wan, Xiaoxiao, Unanue, Emil R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2021
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660984/ https://www.ncbi.nlm.nih.gov/pubmed/34497137 http://dx.doi.org/10.2337/db21-0513

Ejemplares similares

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A
por: Delong, Thomas, et al.
Publicado: (2012)

The MHCII peptidome of the pancreatic islet identifies key features of autoimmune peptides
por: Wan, Xiaoxiao, et al.
Publicado: (2020)

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
por: Nayak, Deepak K., et al.
Publicado: (2014)

Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets
por: Vomund, Anthony N., et al.
Publicado: (2021)

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice
por: Levisetti, Matteo G., et al.
Publicado: (2008)

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
por: Baker, Rocky L., et al.
Publicado: (2019)

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
por: Delong, Thomas, et al.
Publicado: (2011)

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice
por: Carrero, Javier A., et al.
Publicado: (2017)

Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01
por: Arribas-Layton, David, et al.
Publicado: (2020)

Soluble Antigen Arrays Efficiently Deliver Peptides and Arrest Spontaneous Autoimmune Diabetes
por: Firdessa-Fite, Rebuma, et al.
Publicado: (2021)

Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation
por: Wan, Xiaoxiao, et al.
Publicado: (2018)

Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice
por: Ramakrishnan, Parameswaran, et al.
Publicado: (2016)

Mechanisms Underlying Antigen-Specific Tolerance of Stable and Convertible Th17 Cells During Suppression of Autoimmune Diabetes
por: Wan, Xiaoxiao, et al.
Publicado: (2012)

T-Cell Promiscuity in Autoimmune Diabetes
por: Li, Li, et al.
Publicado: (2008)

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides
por: Wan, Xiaoxiao, et al.
Publicado: (2018)

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes
por: Zakharov, Pavel N., et al.
Publicado: (2020)

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
por: Nakayama, Maki, et al.
Publicado: (2012)

Haploidentical haematopoietic stem cell transplantation for thalassaemia major based on an FBCA conditioning regimen
por: Sun, Qixin, et al.
Publicado: (2018)

A Humanized Mouse Model of Autoimmune Insulitis
por: Viehmann Milam, Ashley A., et al.
Publicado: (2014)

Evidence-based, Skin-directed Treatments for Cutaneous Chronic Graft-versus-host Disease
por: Kim, Yoo Jung, et al.
Publicado: (2019)

Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
por: Fiorina, Paolo, et al.
Publicado: (2008)

Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice
por: Obermüller, Stefanie, et al.
Publicado: (2010)

Abatacept GVHD prophylaxis in unrelated hematopoietic cell transplantation for pediatric bone marrow failure
por: Stenger, Elizabeth O., et al.
Publicado: (2023)

Phase II trial of single‐agent panobinostat consolidation improves responses after sub‐optimal transplant outcomes in multiple myeloma
por: Mithraprabhu, Sridurga, et al.
Publicado: (2020)

Children With Islet Autoimmunity and Enterovirus Infection Demonstrate a Distinct Cytokine Profile
por: Yeung, Wing-Chi G., et al.
Publicado: (2012)

Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35
por: Bettini, Maria, et al.
Publicado: (2012)

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
por: Fourlanos, Spiros, et al.
Publicado: (2011)

Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe disease
por: Page, Kristin M., et al.
Publicado: (2022)

Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation in the United States Characterized by Kidney Donor Profile Index
por: Rege, Aparna, et al.
Publicado: (2016)

The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles
por: Zinselmeyer, Bernd H., et al.
Publicado: (2018)

Graft rejection markers in children undergoing hematopoietic cell transplant for bone marrow failure
por: Sabulski, Anthony, et al.
Publicado: (2021)

The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes
por: Azzi, Jamil, et al.
Publicado: (2012)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
por: McGuire, Helen M., et al.
Publicado: (2011)

Unfavorable transcriptome profiles and social disadvantage in hematopoietic cell transplantation: a CIBMTR analysis
por: Taylor, Mallory R., et al.
Publicado: (2023)

Acute GVHD, BK virus hemorrhagic cystitis and age are risk factors for transplant-associated thrombotic microangiopathy in adults
por: Vasu, Sumithira, et al.
Publicado: (2022)

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
por: Faleo, Gaetano, et al.
Publicado: (2012)

HLA-DR Mismatch and Black Race Are Associated With Recurrent Autoimmune Hepatitis After Liver Transplantation
por: McCabe, Marshall, et al.
Publicado: (2021)

Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning
por: Townsend, William M, et al.
Publicado: (2013)

Kidney Transplantation Confers Survival Benefit for Candidates With Pulmonary Hypertension
por: Nguyen, Michelle C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kg7l94f208g9fhbimocqsnm1ev