Cargando…

Synthesis and Evaluation of [(11)C]7-Halogen-2-Phenyl Isoindolone Derivatives: Potential PET Radioligands for in vivo Imaging of 5-HT(2)(C) Receptors

The serotonin 5-HT(2)(C) receptor (5-HT(2)(C)R) is abundantly expressed throughout the central nervous system, and involved in a variety of neuroendocrine and neurobehavioral processes. The development of a selective radioligand that will enable in vivo imaging and quantification of 5-HT(2)(C)R dens...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Fanxing, Nye, Jonathon A., Voll, Ronald J., Mun, Jiyoung, Goodman, Mark M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661056/ https://www.ncbi.nlm.nih.gov/pubmed/34899169 http://dx.doi.org/10.3389/fnins.2021.766320

Ejemplares similares

Concise and Scalable Radiosynthesis of (+)-[(18)F]MDL100907 as a Serotonin 5-HT(2A) Receptor Antagonist for PET
por: Chavan, Lahu N., et al.
Publicado: (2023)

Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense
por: Silva, Daniel G., et al.
Publicado: (2021)

Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents
por: Wang, Yinan, et al.
Publicado: (2021)

Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[(11) C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([(11) C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
por: Fuchigami, Takeshi, et al.
Publicado: (2012)

Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism
por: Hang, Sijin, et al.
Publicado: (2022)

Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [(11)C]KR31173
por: Gulaldi, Nedim C. M., et al.
Publicado: (2013)

A human PET study of [(11)C]HMS011, a potential radioligand for AMPA receptors
por: Takahata, Keisuke, et al.
Publicado: (2017)

ABC transporter-dependent brain uptake of the 5-HT(1B) receptor radioligand [(11)C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig
por: Tóth, Miklós, et al.
Publicado: (2014)

Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2
por: Kaur, Jatinder, et al.
Publicado: (2022)

Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[(11)C]Me-NB1
por: Rischka, Lucas, et al.
Publicado: (2022)

[(11)C]MADAM Used as a Model for Understanding the Radiometabolism of Diphenyl Sulfide Radioligands for Positron Emission Tomography (PET)
por: Gourand, Fabienne, et al.
Publicado: (2015)

Characterization of [(11)C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
por: Yang, Kai-Chun, et al.
Publicado: (2016)

Characterization of a Novel M4 PAM PET Radioligand [11C]PF06885190 in Nonhuman Primates (NHP)
por: Nag, Sangram, et al.
Publicado: (2023)

(11)C-Labeling of Aryl Ketones as Candidate Histamine Subtype-3 Receptor PET Radioligands through Pd(0)-Mediated (11)C-Carbonylative Coupling
por: Siméon, Fabrice G., et al.
Publicado: (2017)

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease
por: Bertoglio, Daniele, et al.
Publicado: (2021)

Potential for imaging the high-affinity state of the 5-HT(1B) receptor: a comparison of three PET radioligands with differing intrinsic activity
por: Lindberg, Anton, et al.
Publicado: (2019)

Development of Novel (11)C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging
por: Rong, Jian, et al.
Publicado: (2023)

Radiation Dosimetry of a Novel Adenosine A(2A) Receptor Radioligand [(11)C]Preladenant Based on PET/CT Imaging and Ex Vivo Biodistribution in Rats
por: Zhou, Xiaoyun, et al.
Publicado: (2016)

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, Andrew J., et al.
Publicado: (2014)

A Novel Marine Pyran-Isoindolone Compound Enhances Fibrin Lysis Mediated by Single-Chain Urokinase-Type Plasminogen Activator
por: Gao, Chunli, et al.
Publicado: (2022)

2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling
por: Cortes-Salva, Michelle Y., et al.
Publicado: (2018)

PET Imaging of VMAT2 with the Novel Radioligand [(18)F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [(11)C]DTBZ and [(18)F]FE-DTBZ
por: Nag, Sangram, et al.
Publicado: (2021)

Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand (11)C-UCB-J
por: Bini, Jason, et al.
Publicado: (2020)

In Vivo Evaluation of (11)C-labeled Three Radioligands for Glycine Transporter 1 in the Mouse Brain
por: Zhang, Ji-chun, et al.
Publicado: (2012)

Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures
por: Venzi, Marcello, et al.
Publicado: (2016)

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
por: Zhang, Xiang, et al.
Publicado: (2014)

Development of a PET radioligand for potassium channels to image CNS demyelination
por: Brugarolas, Pedro, et al.
Publicado: (2018)

A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications
por: Behof, William J., et al.
Publicado: (2021)

Kinetic analysis and test-retest variability of the radioligand [(11)C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
por: Jučaite, Aurelija, et al.
Publicado: (2012)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
por: Richards, Erica M., et al.
Publicado: (2018)

Imaging Evaluation of 5HT(2C) Agonists, [(11)C]WAY-163909 and [(11)C]Vabicaserin, Formed by Pictet–Spengler Cyclization
por: Neelamegam, Ramesh, et al.
Publicado: (2014)

The influence of different cellular environments on PET radioligand binding: An application to D(2/3)-dopamine receptor imaging
por: Quelch, Darren R., et al.
Publicado: (2014)

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
por: Shrestha, Stal, et al.
Publicado: (2020)

Editorial: Development of selective carbon-11 radioligands for target-based PET molecular imaging in oncology, cardiology and neurology
por: Nerella, Sridhar Goud, et al.
Publicado: (2023)

Radiosynthesis and preclinical evaluation of [(11)C]prucalopride as a potential agonist PET ligand for the 5-HT(4) receptor
por: Buiter, Hans JC, et al.
Publicado: (2013)

Human Biodistribution and Dosimetry of (11)C-CUMI-101, an Agonist Radioligand for Serotonin-1A Receptors in Brain
por: Hines, Christina S., et al.
Publicado: (2011)

Kinetic analysis of [(11)C]befloxatone in the human brain, a selective radioligand to image monoamine oxidase A
por: Zanotti-Fregonara, Paolo, et al.
Publicado: (2013)

Synthesis and evaluation of [(11)C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain
por: Yamasaki, Tomoteru, et al.
Publicado: (2013)

Radioligand binding analysis of α(2) adrenoceptors with [(11)C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding
por: Phan, Jenny-Ann, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hjpokbvlt7458hgt3dgg7ajlr3