ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

The purpose of this study was to examine whether the imipridone ONC201/TIC10 affects the metabolic and proliferative activity of medulloblastoma cells in vitro. Preclinical drug testing including extracellular flux analyses (agilent seahorse), MTT assays and Western blot analyses were performed in h...

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Detalles Bibliográficos
Autores principales: Dwucet, Annika, Pruss, Maximilian, Cao, Qiyu, Tanriover, Mine, Prabhu, Varun V., Allen, Joshua E., Peraud, Aurelia, Westhoff, Mike-Andrew, Siegelin, Markus D., Wirtz, Christian Rainer, Karpel-Massler, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661473/
https://www.ncbi.nlm.nih.gov/pubmed/34900991
http://dx.doi.org/10.3389/fcell.2021.734699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661473/
https://www.ncbi.nlm.nih.gov/pubmed/34900991
http://dx.doi.org/10.3389/fcell.2021.734699

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