Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation

[Image: see text] Here we report that chiral Mn(I) complexes are capable of H–P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal−ligand cooperation, a strategy previously not considered for catalytic H–...

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Autores principales: Pérez, Juana M., Postolache, Roxana, Castiñeira Reis, Marta, Sinnema, Esther G., Vargová, Denisa, de Vries, Folkert, Otten, Edwin, Ge, Luo, Harutyunyan, Syuzanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662621/
https://www.ncbi.nlm.nih.gov/pubmed/34797634
http://dx.doi.org/10.1021/jacs.1c10756
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author Pérez, Juana M.
Postolache, Roxana
Castiñeira Reis, Marta
Sinnema, Esther G.
Vargová, Denisa
de Vries, Folkert
Otten, Edwin
Ge, Luo
Harutyunyan, Syuzanna R.
author_facet Pérez, Juana M.
Postolache, Roxana
Castiñeira Reis, Marta
Sinnema, Esther G.
Vargová, Denisa
de Vries, Folkert
Otten, Edwin
Ge, Luo
Harutyunyan, Syuzanna R.
author_sort Pérez, Juana M.
collection PubMed
description [Image: see text] Here we report that chiral Mn(I) complexes are capable of H–P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal−ligand cooperation, a strategy previously not considered for catalytic H–P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.
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spelling pubmed-86626212021-12-10 Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation Pérez, Juana M. Postolache, Roxana Castiñeira Reis, Marta Sinnema, Esther G. Vargová, Denisa de Vries, Folkert Otten, Edwin Ge, Luo Harutyunyan, Syuzanna R. J Am Chem Soc [Image: see text] Here we report that chiral Mn(I) complexes are capable of H–P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal−ligand cooperation, a strategy previously not considered for catalytic H–P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity. American Chemical Society 2021-11-19 2021-12-08 /pmc/articles/PMC8662621/ /pubmed/34797634 http://dx.doi.org/10.1021/jacs.1c10756 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Pérez, Juana M.
Postolache, Roxana
Castiñeira Reis, Marta
Sinnema, Esther G.
Vargová, Denisa
de Vries, Folkert
Otten, Edwin
Ge, Luo
Harutyunyan, Syuzanna R.
Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation
title Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation
title_full Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation
title_fullStr Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation
title_full_unstemmed Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation
title_short Manganese(I)-Catalyzed H–P Bond Activation via Metal–Ligand Cooperation
title_sort manganese(i)-catalyzed h–p bond activation via metal–ligand cooperation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662621/
https://www.ncbi.nlm.nih.gov/pubmed/34797634
http://dx.doi.org/10.1021/jacs.1c10756
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