Two Functional Epithelial Sodium Channel Isoforms Are Present in Rodents despite Pronounced Evolutionary Pseudogenization and Exon Fusion

The epithelial sodium channel (ENaC) plays a key role in salt and water homeostasis in tetrapod vertebrates. There are four ENaC subunits (α, β, γ, δ), forming heterotrimeric αβγ- or δβγ-ENaCs. Although the physiology of αβγ-ENaC is well understood, for decades the field has stalled with respect to...

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Detalles Bibliográficos
Autores principales: Gettings, Sean M, Maxeiner, Stephan, Tzika, Maria, Cobain, Matthew R D, Ruf, Irina, Benseler, Fritz, Brose, Nils, Krasteva-Christ, Gabriela, Vande Velde, Greetje, Schönberger, Matthias, Althaus, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662647/
https://www.ncbi.nlm.nih.gov/pubmed/34491346
http://dx.doi.org/10.1093/molbev/msab271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662647/
https://www.ncbi.nlm.nih.gov/pubmed/34491346
http://dx.doi.org/10.1093/molbev/msab271

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