SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

SHANK2 (ProSAP1) is a postsynaptic scaffolding protein of excitatory synapses in the central nervous system and implicated in the development of autism spectrum disorders (ASD). Patients with mutations in SHANK2 show autism-like behaviors, developmental delay, and intellectual disability. We generat...

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Detalles Bibliográficos
Autores principales: Lutz, Anne-Kathrin, Pérez Arévalo, Andrea, Ioannidis, Valentin, Stirmlinger, Nadine, Demestre, Maria, Delorme, Richard, Bourgeron, Thomas, Boeckers, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662699/
https://www.ncbi.nlm.nih.gov/pubmed/34899182
http://dx.doi.org/10.3389/fnmol.2021.773571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662699/
https://www.ncbi.nlm.nih.gov/pubmed/34899182
http://dx.doi.org/10.3389/fnmol.2021.773571

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