Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages

Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by complement-dependent, fibroblast-induced perivascular accumulation and proinflammatory activation of macrophages. We hypothesized that, in PH, nanoscale-sized small extracellular vesicles (sEVs), released by perivascula...

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Detalles Bibliográficos
Autores principales: Kumar, Sushil, Frid, Maria G., Zhang, Hui, Li, Min, Riddle, Suzette, Brown, R. Dale, Yadav, Subhash Chandra, Roy, Micaela K., Dzieciatkowska, Monika E., D’Alessandro, Angelo, Hansen, Kirk C., Stenmark, Kurt R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663554/
https://www.ncbi.nlm.nih.gov/pubmed/34499621
http://dx.doi.org/10.1172/jci.insight.148382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663554/
https://www.ncbi.nlm.nih.gov/pubmed/34499621
http://dx.doi.org/10.1172/jci.insight.148382

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