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The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function

Foxp3(+) Tregs are potent immunosuppressive CD4(+) T cells that are critical to maintain immune quiescence and prevent autoimmunity. Both the generation and maintenance of Foxp3(+) Tregs depend on the cytokine IL-2. Hence, the expression of the IL-2 receptor α-chain (CD25) is not only considered a s...

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Detalles Bibliográficos
Autores principales: Prakhar, Praveen, Alvarez-DelValle, Jaylene, Keller, Hilary, Crossman, Assiatu, Tai, Xuguang, Park, Yoo Kyoung, Park, Jung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663555/
https://www.ncbi.nlm.nih.gov/pubmed/34747370
http://dx.doi.org/10.1172/jci.insight.149656