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The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function
Foxp3(+) Tregs are potent immunosuppressive CD4(+) T cells that are critical to maintain immune quiescence and prevent autoimmunity. Both the generation and maintenance of Foxp3(+) Tregs depend on the cytokine IL-2. Hence, the expression of the IL-2 receptor α-chain (CD25) is not only considered a s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663555/ https://www.ncbi.nlm.nih.gov/pubmed/34747370 http://dx.doi.org/10.1172/jci.insight.149656 |