CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE

Experimental autoimmune encephalomyelitis (EAE) is a well-characterized animal model of multiple sclerosis. During the early phase of EAE, infiltrating monocytes and monocyte-derived macrophages contribute to T cell recruitment, especially CD4(+) T cells, into the CNS, resulting in neuronal demyelin...

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Detalles Bibliográficos
Autores principales: Wang, Huan, Newton, Gail, Wu, Liguo, Lin, Lih-Ling, Miracco, Amy S., Natesan, Sridaran, Luscinskas, Francis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663579/
https://www.ncbi.nlm.nih.gov/pubmed/34591795
http://dx.doi.org/10.1172/jci.insight.148719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663579/
https://www.ncbi.nlm.nih.gov/pubmed/34591795
http://dx.doi.org/10.1172/jci.insight.148719

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