Cargando…

CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE

Experimental autoimmune encephalomyelitis (EAE) is a well-characterized animal model of multiple sclerosis. During the early phase of EAE, infiltrating monocytes and monocyte-derived macrophages contribute to T cell recruitment, especially CD4(+) T cells, into the CNS, resulting in neuronal demyelin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Huan, Newton, Gail, Wu, Liguo, Lin, Lih-Ling, Miracco, Amy S., Natesan, Sridaran, Luscinskas, Francis W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663579/ https://www.ncbi.nlm.nih.gov/pubmed/34591795 http://dx.doi.org/10.1172/jci.insight.148719

Ejemplares similares

Role of Microglia and Macrophages in Eae
por: Raivich, Gennadij, et al.
Publicado: (2005)

Comparative Review of Microglia and Monocytes in CNS Phagocytosis
por: Andoh, Megumi, et al.
Publicado: (2021)

CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils
por: Haj-Yehia, Elias, et al.
Publicado: (2023)

SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen
por: Autio, Anu, et al.
Publicado: (2022)

Phagocytosis converts infiltrated monocytes to microglia-like phenotype in experimental brain ischemia
por: Ju, Hyunwoo, et al.
Publicado: (2022)

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair
por: Zhang, Shuang, et al.
Publicado: (2017)

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice
por: Engelbertsen, Daniel, et al.
Publicado: (2019)

Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages
por: Zeller, Tobias, et al.
Publicado: (2022)

CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer
por: Gu, Shenglan, et al.
Publicado: (2018)

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
por: Brauneck, Franziska, et al.
Publicado: (2022)

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade
por: Anderson, Katie L., et al.
Publicado: (2020)

CD47 promotes ovarian cancer progression by inhibiting macrophage phagocytosis
por: Liu, Ran, et al.
Publicado: (2017)

Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation
por: Li, Zhiqiang, et al.
Publicado: (2021)

Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo.
por: Azcutia, Veronica, et al.
Publicado: (2020)

Aging and sex: Impact on microglia phagocytosis
por: Yanguas‐Casás, Natalia, et al.
Publicado: (2020)

Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
por: Park, Sung Hee, et al.
Publicado: (2021)

Activation of phagocytosis by immune checkpoint blockade
por: Li, Chia-Wei, et al.
Publicado: (2018)

Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish
por: Yang, Dai-xiao, et al.
Publicado: (2021)

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE
por: Jakovljevic, Marija, et al.
Publicado: (2019)

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
por: Gitik, Miri, et al.
Publicado: (2011)

Phagocytosis of Microglia in the Central Nervous System Diseases
por: Fu, Ruying, et al.
Publicado: (2014)

Regulation of microglia phagocytosis and potential involvement of exercise
por: Li, Congqin, et al.
Publicado: (2022)

CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis
por: Kojima, Yoko, et al.
Publicado: (2016)

Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation
por: Suter, Emily C., et al.
Publicado: (2021)

Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis
por: Lu, Xin-Jiang, et al.
Publicado: (2019)

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE
por: Wlodarczyk, Agnieszka, et al.
Publicado: (2019)

Dysregulation of Blood-Brain Barrier and Exacerbated Inflammatory Response in Cx47-Deficient Mice after Induction of EAE
por: Stavropoulos, Filippos, et al.
Publicado: (2021)

Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia
por: Cockram, Tom O. J., et al.
Publicado: (2019)

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions
por: Azcutia, Veronica, et al.
Publicado: (2013)

Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD
por: Singh, R., et al.
Publicado: (2021)

Presepsin production in monocyte/macrophage-mediated phagocytosis of neutrophil extracellular traps
por: Ikegame, Akishige, et al.
Publicado: (2022)

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages
Publicado: (1982)

EAES Recommendations for Recovery Plan in Minimally Invasive Surgery Amid COVID-19 Pandemic
por: Arezzo, Alberto, et al.
Publicado: (2020)

MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47
por: Huang, Wei, et al.
Publicado: (2018)

Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis
por: He, Yuan, et al.
Publicado: (2019)

Tristetraprolin regulates phagocytosis through interaction with CD47 in head and neck cancer
por: Lee, Won Hyeok, et al.
Publicado: (2022)

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
por: Neher, Jonas J., et al.
Publicado: (2012)

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
por: Sierra, Amanda, et al.
Publicado: (2013)

Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine
por: Fan, Yang, et al.
Publicado: (2018)

Transcriptional signature in microglia associated with Aβ plaque phagocytosis
por: Grubman, Alexandra, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7m061ttp9n0bi5n2f0tpl4seh9