Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway

Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein progranulin (PGRN), are associated with several neurodegenerative diseases, including frontotemporal lobar degeneration, neuronal ceroid lipofuscinosis, and Alzheimer’s disease. These genetic alterations manifest in patholog...

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Detalles Bibliográficos
Autores principales: Dong, Tingting, Tejwani, Leon, Jung, Youngseob, Kokubu, Hiroshi, Luttik, Kimberly, Driessen, Terri M., Lim, Janghoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663778/
https://www.ncbi.nlm.nih.gov/pubmed/34618685
http://dx.doi.org/10.1172/jci.insight.136147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663778/
https://www.ncbi.nlm.nih.gov/pubmed/34618685
http://dx.doi.org/10.1172/jci.insight.136147

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