Bupivacaine in combination with sildenafil (Viagra) and vitamin D3 have anti-inflammatory effects in osteoarthritic chondrocytes

AIMS: To treat osteoarthritic chondrocytes and thereby reduce the inflammation with a drug combination that primarily affects 5-HT- and ATP-evoked Ca(2+) signaling. In osteoarthritic chondrocytes, Ca(2+) signaling is elevated, resulting in increased production of ATP and inflammatory mediators. The...

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Detalles Bibliográficos
Autores principales: Hansson, Elisabeth, Skiöldebrand, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663929/
https://www.ncbi.nlm.nih.gov/pubmed/34909684
http://dx.doi.org/10.1016/j.crphar.2021.100066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663929/
https://www.ncbi.nlm.nih.gov/pubmed/34909684
http://dx.doi.org/10.1016/j.crphar.2021.100066

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