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Bupivacaine in combination with sildenafil (Viagra) and vitamin D3 have anti-inflammatory effects in osteoarthritic chondrocytes
AIMS: To treat osteoarthritic chondrocytes and thereby reduce the inflammation with a drug combination that primarily affects 5-HT- and ATP-evoked Ca(2+) signaling. In osteoarthritic chondrocytes, Ca(2+) signaling is elevated, resulting in increased production of ATP and inflammatory mediators. The...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663929/ https://www.ncbi.nlm.nih.gov/pubmed/34909684 http://dx.doi.org/10.1016/j.crphar.2021.100066 |