Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm

Receptor tyrosine kinases (RTKs) have become major targets for anticancer therapy. However, resistance and signaling pathway redundancy has been problematic. The marine-derived apratoxins act complementary to direct kinase inhibitors by downregulating the levels of multiple of these receptors and ad...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Weijing, Ratnayake, Ranjala, Wang, Mengxiong, Chen, Qi-Yin, Raisch, Kevin P., Dang, Long H., Law, Brian K., Luesch, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663948/
https://www.ncbi.nlm.nih.gov/pubmed/34909679
http://dx.doi.org/10.1016/j.crphar.2021.100053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663948/
https://www.ncbi.nlm.nih.gov/pubmed/34909679
http://dx.doi.org/10.1016/j.crphar.2021.100053

Ejemplares similares