Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 ​cells to deliver of GDNF to the brain. In vivo studies demonstrated...

Descripción completa

Detalles Bibliográficos
Autores principales: Wahlberg, Lars U., Emerich, Dwaine F., Kordower, Jeffrey H., Bell, William, Fradet, Tracie, Paolone, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663965/
https://www.ncbi.nlm.nih.gov/pubmed/34909639
http://dx.doi.org/10.1016/j.crphar.2020.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663965/
https://www.ncbi.nlm.nih.gov/pubmed/34909639
http://dx.doi.org/10.1016/j.crphar.2020.04.001

Ejemplares similares