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Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 cells to deliver of GDNF to the brain. In vivo studies demonstrated...

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Detalles Bibliográficos
Autores principales:	Wahlberg, Lars U., Emerich, Dwaine F., Kordower, Jeffrey H., Bell, William, Fradet, Tracie, Paolone, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663965/ https://www.ncbi.nlm.nih.gov/pubmed/34909639 http://dx.doi.org/10.1016/j.crphar.2020.04.001

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