Cargando…
A narrative review of genetic factors affecting fluoropyrimidine toxicity
OBJECTIVE: Our objective is to document progress in developing personalized therapy with fluoropyrimidine drugs (FPs) to improve outcomes for cancer patients and to identify areas requiring further investigation. BACKGROUND: FPs including 5-fluorouracil (5-FU), are among the most widely used drugs f...
Autor principal: | Gmeiner, William H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664072/ https://www.ncbi.nlm.nih.gov/pubmed/34901834 http://dx.doi.org/10.21037/pcm-21-17 |
Ejemplares similares
-
Fluoropyrimidine Modulation of the Anti-Tumor Immune Response―Prospects for Improved Colorectal Cancer Treatment
por: Gmeiner, William H.
Publicado: (2020) -
Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature
por: Hodroj, K., et al.
Publicado: (2021) -
Individualized Dosing of Fluoropyrimidine‐Based Chemotherapy to Prevent Severe Fluoropyrimidine‐Related Toxicity: What Are the Options?
por: Knikman, Jonathan E., et al.
Publicado: (2020) -
Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition
por: Mani, Chinnadurai, et al.
Publicado: (2018) -
Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk
por: De Mattia, Elena, et al.
Publicado: (2022)