Targeting metabotropic glutamate receptor 4 for cancer immunotherapy

In this study, we report a novel role of metabotropic glutamate receptor 4 (GRM4) in suppressing antitumor immunity. We revealed in three murine syngeneic tumor models (B16, MC38, and 3LL) that either genetic knockout (Grm4(−/−)) or pharmacological inhibition led to significant delay in tumor growth...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Zhuoya, Sun, Runzi, Liu, Yang-Wuyue, Li, Sihan, Sun, Jingjing, Li, Jiang, Zhu, Junjie, Moharil, Pearl, Zhang, Bei, Ren, Pengfei, Ren, Guolian, Zhang, Min, Ma, Xiaochao, Dai, Shuangshuang, Yang, Da, Lu, Binfeng, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664261/
https://www.ncbi.nlm.nih.gov/pubmed/34890233
http://dx.doi.org/10.1126/sciadv.abj4226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664261/
https://www.ncbi.nlm.nih.gov/pubmed/34890233
http://dx.doi.org/10.1126/sciadv.abj4226

Ejemplares similares