Cargando…

Targeting metabotropic glutamate receptor 4 for cancer immunotherapy

In this study, we report a novel role of metabotropic glutamate receptor 4 (GRM4) in suppressing antitumor immunity. We revealed in three murine syngeneic tumor models (B16, MC38, and 3LL) that either genetic knockout (Grm4(−/−)) or pharmacological inhibition led to significant delay in tumor growth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wan, Zhuoya, Sun, Runzi, Liu, Yang-Wuyue, Li, Sihan, Sun, Jingjing, Li, Jiang, Zhu, Junjie, Moharil, Pearl, Zhang, Bei, Ren, Pengfei, Ren, Guolian, Zhang, Min, Ma, Xiaochao, Dai, Shuangshuang, Yang, Da, Lu, Binfeng, Li, Song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664261/ https://www.ncbi.nlm.nih.gov/pubmed/34890233 http://dx.doi.org/10.1126/sciadv.abj4226

Ejemplares similares

Concerted conformational changes control metabotropic glutamate receptor activity
por: Lecat-Guillet, Nathalie, et al.
Publicado: (2023)

Amphiregulin couples IL1RL1(+) regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity
por: Sun, Runzi, et al.
Publicado: (2023)

Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response
por: Wang, Yifei, et al.
Publicado: (2022)

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1
por: Xi, Yue, et al.
Publicado: (2021)

Metabotropic glutamate receptor 5 deficiency inhibits neutrophil infiltration after traumatic brain injury in mice
por: Yang, Ting, et al.
Publicado: (2017)

Polymeric Micelles in Cancer Immunotherapy
por: Wan, Zhuoya, et al.
Publicado: (2021)

Interdependence of a mechanosensitive anion channel and glutamate receptors in distal wound signaling
por: Moe-Lange, Jacob, et al.
Publicado: (2021)

Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
por: Wei, Peng, et al.
Publicado: (2022)

Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation
por: Guo, Ziyi, et al.
Publicado: (2022)

Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy
por: Chen, Yu-Jia, et al.
Publicado: (2023)

RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis
por: Qian, Baomei, et al.
Publicado: (2022)

Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors
por: Ren, Yuan, et al.
Publicado: (2023)

Structure of a diatom photosystem II supercomplex containing a member of Lhcx family and dimeric FCPII
por: Feng, Yue, et al.
Publicado: (2023)

Gain-of-function mutations in the catalytic domain of DOT1L promote lung cancer malignant phenotypes via the MAPK/ERK signaling pathway
por: Zhang, Jiayu, et al.
Publicado: (2023)

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets
por: Han, Yi, et al.
Publicado: (2023)

FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium
por: Ba, Ru, et al.
Publicado: (2023)

NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance
por: Yang, Jin-Ming, et al.
Publicado: (2022)

Natural flavonoids disrupt bacterial iron homeostasis to potentiate colistin efficacy
por: Zhong, Zi-xing, et al.
Publicado: (2023)

Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes
por: Ren, Xingxing, et al.
Publicado: (2023)

A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
por: Shi, Chengxin, et al.
Publicado: (2022)

CancerVar: An artificial intelligence–empowered platform for clinical interpretation of somatic mutations in cancer
por: Li, Quan, et al.
Publicado: (2022)

Global crotonylatome and GWAS revealed a TaSRT1-TaPGK model regulating wheat cold tolerance through mediating pyruvate
por: Zhang, Ning, et al.
Publicado: (2023)

Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma
por: Jiang, Yu, et al.
Publicado: (2023)

Loss-of-function mutations in CEP78 cause male infertility in humans and mice
por: Zhang, Xueguang, et al.
Publicado: (2022)

A nitrogen fixing symbiosis-specific pathway required for legume flowering
por: Yun, Jinxia, et al.
Publicado: (2023)

Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor
por: Ren, Yujie, et al.
Publicado: (2023)

Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32
por: Mi, Chenchen, et al.
Publicado: (2022)

Na, K-ATPase α1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape
por: Yang, Kaiyong, et al.
Publicado: (2023)

Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity
por: Chen, Xiufei, et al.
Publicado: (2022)

DExD/H-box helicase 9 intrinsically controls CD8(+) T cell–mediated antiviral response through noncanonical mechanisms
por: Jiao, Anjun, et al.
Publicado: (2022)

Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation in Arabidopsis
por: Yu, Zipeng, et al.
Publicado: (2023)

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
por: Jia, Mengshu, et al.
Publicado: (2023)

An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression
por: Wang, Liu, et al.
Publicado: (2021)

Recapitulating hepatitis E virus–host interactions and facilitating antiviral drug discovery in human liver–derived organoids
por: Li, Pengfei, et al.
Publicado: (2022)

Lactate induces vascular permeability via disruption of VE-cadherin in endothelial cells during sepsis
por: Yang, Kun, et al.
Publicado: (2022)

Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes
por: Xu, Chang, et al.
Publicado: (2021)

Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath
por: Ren, Xingjie, et al.
Publicado: (2021)

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
por: Liu, Chao, et al.
Publicado: (2023)

Genotype-specific precision tumor therapy using mitochondrial DNA mutation-induced drug release system
por: Li, Yanan, et al.
Publicado: (2023)

Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure
por: Ren, Hui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3e7ilnrgobr9117di3923ba66a