Induction of Cross-Reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-Cell Responses by a Recombinant Matrix-M–Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine

BACKGROUND: Recurrent reports of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the safety and immunogenicity of a novel, saponin (Matrix-M)–adjuvanted, recombinant hemagglutinin (HA) quadrivalent nan...

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Detalles Bibliográficos
Autores principales: Shinde, Vivek, Cai, Rongman, Plested, Joyce, Cho, Iksung, Fiske, Jamie, Pham, Xuan, Zhu, Mingzhu, Cloney-Clark, Shane, Wang, Nan, Zhou, Haixia, Zhou, Bin, Patel, Nita, Massare, Michael J, Fix, Amy, Spindler, Michelle, Thomas, David Nigel, Smith, Gale, Fries, Louis, Glenn, Gregory M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664440/
https://www.ncbi.nlm.nih.gov/pubmed/33146720
http://dx.doi.org/10.1093/cid/ciaa1673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664440/
https://www.ncbi.nlm.nih.gov/pubmed/33146720
http://dx.doi.org/10.1093/cid/ciaa1673

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