Cargando…

Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections

It has been estimated that 15%–30% of the ∼20,000 genes in C. elegans are essential, yet many of these genes remain to be identified or characterized. With the goal of identifying unknown essential genes, we performed whole-genome sequencing on complementation pairs from legacy collections of matern...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li-Leger, Erica, Feichtinger, Richard, Flibotte, Stephane, Holzkamp, Heinke, Schnabel, Ralf, Moerman, Donald G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664450/ https://www.ncbi.nlm.nih.gov/pubmed/34550348 http://dx.doi.org/10.1093/g3journal/jkab328

Ejemplares similares

CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans
por: Au, Vinci, et al.
Publicado: (2018)

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans
por: Itani, Omar A., et al.
Publicado: (2015)

Unexpected Role for Dosage Compensation in the Control of Dauer Arrest, Insulin-Like Signaling, and FoxO Transcription Factor Activity in Caenorhabditis elegans
por: Dumas, Kathleen J., et al.
Publicado: (2013)

The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans
por: Lissemore, James L., et al.
Publicado: (2018)

MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes
por: Mok, Calvin A., et al.
Publicado: (2017)

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans
por: Safdar, Komal, et al.
Publicado: (2016)

A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in Caenorhabditis elegans
por: Ye, Frank B., et al.
Publicado: (2020)

Genetic Control of Vulval Development in Caenorhabditis briggsae
por: Sharanya, Devika, et al.
Publicado: (2012)

Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans
por: Maydan, Jason S, et al.
Publicado: (2010)

N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3′ Splice Site Function in Vivo
por: Itani, Omar A., et al.
Publicado: (2016)

A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans
por: Li, Shiwei, et al.
Publicado: (2016)

Visualization and Quantification of Transposon Activity in Caenorhabditis elegans RNAi Pathway Mutants
por: Wallis, Dylan C., et al.
Publicado: (2019)

Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans
por: Qin, Zhaozhao, et al.
Publicado: (2018)

Automated and customizable quantitative image analysis of whole Caenorhabditis elegans germlines
por: Toraason, Erik, et al.
Publicado: (2021)

Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis
por: Gönczy, Pierre, et al.
Publicado: (1999)

PhenoMIP: High-Throughput Phenotyping of Diverse Caenorhabditis elegans Populations via Molecular Inversion Probes
por: Mok, Calvin, et al.
Publicado: (2020)

Oligonucleotide Array Comparative Genomic Hybridization (oaCGH) based characterization of genetic deficiencies as an aid to gene mapping in Caenorhabditis elegans
por: Jones, Martin R, et al.
Publicado: (2007)

A Network of HSPG Core Proteins and HS Modifying Enzymes Regulates Netrin-Dependent Guidance of D-Type Motor Neurons in Caenorhabditis elegans
por: Gysi, Stephan, et al.
Publicado: (2013)

Correction: A Network of HSPG Core Proteins and HS Modifying Enzymes Regulates Netrin-Dependent Guidance of D-Type Motor Neurons in Caenorhabditis elegans
por: Gysi, Stephan, et al.
Publicado: (2014)

Genomic sequence of a mutant strain of Caenorhabditis elegans with an altered recombination pattern
por: Rose, Ann M, et al.
Publicado: (2010)

Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants
por: Wolters, Stefanie, et al.
Publicado: (2014)

Cross Talk with the GAR-3 Receptor Contributes to Feeding Defects in Caenorhabditis elegans eat-2 Mutants
por: Kozlova, Alena A., et al.
Publicado: (2019)

Noncanonical necrosis in 2 different cell types in a Caenorhabditis elegans NAD(+) salvage pathway mutant
por: Reza, Rifath N, et al.
Publicado: (2022)

α spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans
por: Norman, Kenneth R., et al.
Publicado: (2002)

A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2
por: Wiesenfahrt, Tobias, et al.
Publicado: (2018)

Widespread Genomic Incompatibilities in Caenorhabditis elegans
por: Snoek, L. Basten, et al.
Publicado: (2014)

Identifying the Caenorhabditis elegans vulval transcriptome
por: Zhang, Qi, et al.
Publicado: (2022)

Formation and function of dauer ascarosides in the nematodes Caenorhabditis briggsae and Caenorhabditis elegans
por: Cohen, Sarah M, et al.
Publicado: (2022)

High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects
por: Lowry, Josh, et al.
Publicado: (2015)

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans
por: Chen, Albert Tzong-Yang, et al.
Publicado: (2015)

An Efficient Genome Editing Strategy To Generate Putative Null Mutants in Caenorhabditis elegans Using CRISPR/Cas9
por: Wang, Han, et al.
Publicado: (2018)

Use of a Sibling Subtraction Method for Identifying Causal Mutations in Caenorhabditis elegans by Whole-Genome Sequencing
por: Joseph, Braveen B., et al.
Publicado: (2017)

Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans
por: Farslow, James C., et al.
Publicado: (2015)

Orthologs of the Caenorhabditis elegans heterochronic genes have divergent functions in Caenorhabditis briggsae
por: Ivanova, Maria, et al.
Publicado: (2023)

HES-Mediated Repression of Pten in Caenorhabditis elegans
por: Chou, Han Ting, et al.
Publicado: (2015)

Genetic Identification of Separase Regulators in Caenorhabditis elegans
por: Melesse, Michael, et al.
Publicado: (2017)

Synaptogenesis Is Modulated by Heparan Sulfate in Caenorhabditis elegans
por: Lázaro-Peña, María I., et al.
Publicado: (2018)

Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans
por: Gee, Kevin, et al.
Publicado: (2017)

Taxonomically Restricted Genes with Essential Functions Frequently Play Roles in Chromosome Segregation in Caenorhabditis elegans and Saccharomyces cerevisiae
por: Verster, Adrian J., et al.
Publicado: (2017)

Chromosome Movements Promoted by the Mitochondrial Protein SPD-3 Are Required for Homology Search during Caenorhabditis elegans Meiosis
por: Labrador, Leticia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_3qf7ffko2dvpame44vkq749sn5