A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington’s disease

The Ataxin-2 (Atx2) protein contributes to the progression of neurodegenerative phenotypes in animal models of amyotrophic lateral sclerosis (ALS), type 2 spinocerebellar ataxia (SCA-2), Parkinson’s disease, and Huntington’s disease (HD). However, because the Atx2 protein contains multiple separable...

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Detalles Bibliográficos
Autores principales: Huelsmeier, Joern, Walker, Emily, Bakthavachalu, Baskar, Ramaswami, Mani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664476/
https://www.ncbi.nlm.nih.gov/pubmed/34718534
http://dx.doi.org/10.1093/g3journal/jkab355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664476/
https://www.ncbi.nlm.nih.gov/pubmed/34718534
http://dx.doi.org/10.1093/g3journal/jkab355

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