Cargando…

Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer's Disease Animal Model

Alzheimer's disease (AD) animal studies have reported that mesenchymal stem cells (MSCs) have therapeutic effects; however, clinical trial results are controversial. Neprilysin (NEP) is the main cleavage enzyme of β-amyloid (Aβ), which plays a major role in the pathology and etiology of AD. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, HyeJu, Kim, Ok Joon, Oh, Seung-Hun, Lee, Sanghoon, Reum Lee, Han A., Lee, Kee Ook, Lee, Boo-Yong, Kim, Nam Keun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664527/ https://www.ncbi.nlm.nih.gov/pubmed/34899919 http://dx.doi.org/10.1155/2021/5548630

Ejemplares similares

Enhancing the Therapeutic Potential of CCL2-Overexpressing Mesenchymal Stem Cells in Acute Stroke
por: Lee, Sanghun, et al.
Publicado: (2020)

Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Viruses
por: Oh, Soo-Jin, et al.
Publicado: (2022)

Bolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media
por: Kim, Jun Yong, et al.
Publicado: (2022)

Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles
por: Rodrigues, Silvia C., et al.
Publicado: (2021)

Extracellular Vesicles as a Neprilysin Delivery System Memory Improvement in Alzheimer’s Disease
por: Izadpanah, Mehrnaz, et al.
Publicado: (2020)

Differential Impact of Plasma Homocysteine Levels on the Periventricular and Subcortical White Matter Hyperintensities on the Brain
por: Lee, Kee Ook, et al.
Publicado: (2019)

Bacterial extracellular vesicles affect endocrine therapy in MCF7 cells
por: An, Jeongshin, et al.
Publicado: (2021)

Extracellular Vesicles Derived from Three-Dimensional-Cultured Human Umbilical Cord Blood Mesenchymal Stem Cells Prevent Inflammation and Dedifferentiation in Pancreatic Islets
por: Lee, Eunwon, et al.
Publicado: (2023)

The Potential Roles of Extracellular Vesicles in Cigarette Smoke-Associated Diseases
por: Ryu, A-Reum, et al.
Publicado: (2018)

Blood Neutrophil/Lymphocyte Ratio Is Associated With Cerebral Large-Artery Atherosclerosis but Not With Cerebral Small-Vessel Disease
por: Chung, Darda, et al.
Publicado: (2020)

Induction of Corneal Endothelial-like Cells from Mesenchymal Stem Cells of the Umbilical Cord
por: Ye, Eun Ah, et al.
Publicado: (2022)

Interleukin-1 receptor antagonist-mediated neuroprotection by umbilical cord-derived mesenchymal stromal cells following transplantation into a rodent stroke model
por: Oh, Seung-Hun, et al.
Publicado: (2018)

Correlations between the Status of the Umbilical Cord and Neonatal Health Status
por: Lee, Sun Min, et al.
Publicado: (2020)

Procoagulant Activity of Umbilical Cord-Derived Mesenchymal Stromal Cells’ Extracellular Vesicles (MSC-EVs)
por: Wright, Adrienne, et al.
Publicado: (2023)

Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro
por: Xie, Min, et al.
Publicado: (2022)

Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles
por: Hyland, Mairead, et al.
Publicado: (2020)

Amelioration of ligamentum flavum hypertrophy using umbilical cord mesenchymal stromal cell-derived extracellular vesicles
por: Ma, Cheng, et al.
Publicado: (2022)

MiR-10a, 27a, 34b/c, and 300 Polymorphisms are Associated with Ischemic Stroke Susceptibility and Post-Stroke Mortality
por: Ryu, Chang Soo, et al.
Publicado: (2020)

Extracellular vesicles for neural regeneration after spinal cord injury
por: Lim, Young-Ju, et al.
Publicado: (2023)

Extracellular vesicles from human umbilical cord blood plasma modulate interleukin-2 signaling of T cells to ameliorate experimental autoimmune encephalomyelitis
por: Kim, Sueon, et al.
Publicado: (2020)

Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis
por: Chen, Wenbiao, et al.
Publicado: (2022)

Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release
por: Davies, Rebecca, et al.
Publicado: (2023)

Tumorigenicity Evaluation of Umbilical Cord Blood-derived Mesenchymal Stem Cells
por: Park, Sang-Jin, et al.
Publicado: (2016)

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
por: Morhayim, Jess, et al.
Publicado: (2016)

Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders
por: Rodrigues, Sílvia C., et al.
Publicado: (2021)

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Attenuate Mast Cell Activation
por: Lin, Tzou-Yien, et al.
Publicado: (2022)

Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes
por: Nguyen, Thu Huyen, et al.
Publicado: (2022)

Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats
por: Chung, Hyo-jin, et al.
Publicado: (2016)

Safety of umbilical cord milking in very preterm neonates: a randomized controlled study
por: Song, Soo-Youn, et al.
Publicado: (2017)

Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients
por: Hwang, Hyeon Seok, et al.
Publicado: (2021)

Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles
por: Youn, Young-Jin, et al.
Publicado: (2021)

Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor
por: Kim, Moo Jun, et al.
Publicado: (2021)

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases
por: Nassar, Wael, et al.
Publicado: (2016)

Preparation of Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells with Ultrasonication for Skin Rejuvenation
por: Wang, Lixue, et al.
Publicado: (2019)

Development of an optimized and scalable method for isolation of umbilical cord blood‐derived small extracellular vesicles for future clinical use
por: Cardoso, Renato M. S., et al.
Publicado: (2021)

Comparison of Curative Effect of Human Umbilical Cord-Derived Mesenchymal Stem Cells and Their Small Extracellular Vesicles in Treating Osteoarthritis
por: Tang, Shijie, et al.
Publicado: (2021)

Human Umbilical Cord Blood Endothelial Progenitor Cell-Derived Extracellular Vesicles Control Important Endothelial Cell Functions
por: Ben Fraj, Sawssen, et al.
Publicado: (2023)

Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine
por: Sultana, Tania, et al.
Publicado: (2018)

Oviduct Epithelial Cell-Derived Extracellular Vesicles Improve Porcine Trophoblast Outgrowth
por: Fang, Xun, et al.
Publicado: (2022)

Physician adherence and patient-reported outcomes in heart failure with reduced ejection fraction in the era of angiotensin receptor-neprilysin inhibitor therapy
por: Kim, In-Cheol, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7iupit6pk46vi5dreien9k2ehu