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Cellular variability of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is an mRNA degradation pathway that eliminates transcripts containing premature termination codons (PTCs). Half-lives of the mRNAs containing PTCs demonstrate that a small percent escape surveillance and do not degrade. It is not known whether this escape represent...

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Detalles Bibliográficos
Autores principales: Sato, Hanae, Singer, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664836/
https://www.ncbi.nlm.nih.gov/pubmed/34893608
http://dx.doi.org/10.1038/s41467-021-27423-0