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Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA

Osteosarcoma (OS) is the most common primary bone tumor. Its high mortality rate and metastasis rate seriously threaten human health. Currently, the treatment has reached a plateau, hence we urgently need to explore new therapeutic directions. In this paper, we found that Trio was highly expressed i...

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Autores principales: Wang, Junyi, Yuan, Lichan, Xu, Xiaohong, Zhang, Zhongyin, Ma, Yuhuan, Hong, Leilei, Ma, Junqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664940/
https://www.ncbi.nlm.nih.gov/pubmed/34893584
http://dx.doi.org/10.1038/s41419-021-04448-3
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author Wang, Junyi
Yuan, Lichan
Xu, Xiaohong
Zhang, Zhongyin
Ma, Yuhuan
Hong, Leilei
Ma, Junqing
author_facet Wang, Junyi
Yuan, Lichan
Xu, Xiaohong
Zhang, Zhongyin
Ma, Yuhuan
Hong, Leilei
Ma, Junqing
author_sort Wang, Junyi
collection PubMed
description Osteosarcoma (OS) is the most common primary bone tumor. Its high mortality rate and metastasis rate seriously threaten human health. Currently, the treatment has reached a plateau, hence we urgently need to explore new therapeutic directions. In this paper, we found that Trio was highly expressed in osteosarcoma than normal tissues and promoted the proliferation, migration, and invasion of osteosarcoma cells. Furthermore, Trio inhibited osteosarcoma cells’ osteogenic differentiation in vitro and accelerated the growth of osteosarcoma in vivo. Given Trio contains two GEF domains, which have been reported as the regulators of RhoGTPases, we further discovered that Trio could regulate osteosarcoma progression and osteogenic differentiation through activating RhoGTPases. In summary, all our preliminary results showed that Trio could be a potential target and prognostic marker of osteosarcoma.
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spelling pubmed-86649402021-12-27 Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA Wang, Junyi Yuan, Lichan Xu, Xiaohong Zhang, Zhongyin Ma, Yuhuan Hong, Leilei Ma, Junqing Cell Death Dis Article Osteosarcoma (OS) is the most common primary bone tumor. Its high mortality rate and metastasis rate seriously threaten human health. Currently, the treatment has reached a plateau, hence we urgently need to explore new therapeutic directions. In this paper, we found that Trio was highly expressed in osteosarcoma than normal tissues and promoted the proliferation, migration, and invasion of osteosarcoma cells. Furthermore, Trio inhibited osteosarcoma cells’ osteogenic differentiation in vitro and accelerated the growth of osteosarcoma in vivo. Given Trio contains two GEF domains, which have been reported as the regulators of RhoGTPases, we further discovered that Trio could regulate osteosarcoma progression and osteogenic differentiation through activating RhoGTPases. In summary, all our preliminary results showed that Trio could be a potential target and prognostic marker of osteosarcoma. Nature Publishing Group UK 2021-12-11 /pmc/articles/PMC8664940/ /pubmed/34893584 http://dx.doi.org/10.1038/s41419-021-04448-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Junyi
Yuan, Lichan
Xu, Xiaohong
Zhang, Zhongyin
Ma, Yuhuan
Hong, Leilei
Ma, Junqing
Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
title Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
title_full Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
title_fullStr Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
title_full_unstemmed Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
title_short Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
title_sort rho-gef trio regulates osteosarcoma progression and osteogenic differentiation through rac1 and rhoa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664940/
https://www.ncbi.nlm.nih.gov/pubmed/34893584
http://dx.doi.org/10.1038/s41419-021-04448-3
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