ERK and p38 MAPK inhibition controls NF-E2 degradation and profibrotic signaling in renal proximal tubule cells

AIMS: Transforming growth factor-β (TGF-β) mediates fibrotic manifestations of diabetic nephropathy. We demonstrated proteasomal degradation of anti-fibrotic protein, nuclear factor-erythroid derived 2 (NF-E2), in TGF-β treated human renal proximal tubule (HK-11) cells and in diabetic mouse kidneys....

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Detalles Bibliográficos
Autores principales: Li, Jia, Jin, Shunying, Barati, Michelle T., Rane, Sanjana, Lin, Qian, Tan, Yi, Cai, Lu, Rane, Madhavi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665041/
https://www.ncbi.nlm.nih.gov/pubmed/34715142
http://dx.doi.org/10.1016/j.lfs.2021.120092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665041/
https://www.ncbi.nlm.nih.gov/pubmed/34715142
http://dx.doi.org/10.1016/j.lfs.2021.120092

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