Cargando…

On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state

A small-scale two-stage biphasic system, a small-scale two-stage dissolution-permeation system, the Erweka mini-paddle apparatus, and the BioGIT system were evaluated for their usefulness in assessing the intraluminal performance of two low solubility drugs in the fasted state, one with weakly acidi...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Dwyer, Patrick J, Box, Karl J, Imanidis, Georgios, Vertzoni, Maria, Reppas, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665220/
https://www.ncbi.nlm.nih.gov/pubmed/34628003
http://dx.doi.org/10.1016/j.ejps.2021.106034