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On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state
A small-scale two-stage biphasic system, a small-scale two-stage dissolution-permeation system, the Erweka mini-paddle apparatus, and the BioGIT system were evaluated for their usefulness in assessing the intraluminal performance of two low solubility drugs in the fasted state, one with weakly acidi...
Autores principales: | O'Dwyer, Patrick J, Box, Karl J, Imanidis, Georgios, Vertzoni, Maria, Reppas, Christos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science B.V
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665220/ https://www.ncbi.nlm.nih.gov/pubmed/34628003 http://dx.doi.org/10.1016/j.ejps.2021.106034 |
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