FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity

Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopamine neurons in the substantia nigra. Mutations in the F-box only protein 7 gene (Fbxo7) have been reported to cause an autosomal recessive form of early-onset familial PD. FBXO7 is a part of the SKP1-Cullin1-F-box (SC...

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Detalles Bibliográficos
Autores principales: Lee, Su Hyoun, Jung, Sungyeon, Lee, Yun Ju, Hyun, Minju, Chung, Kwang Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665361/
https://www.ncbi.nlm.nih.gov/pubmed/34800438
http://dx.doi.org/10.1016/j.jbc.2021.101426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665361/
https://www.ncbi.nlm.nih.gov/pubmed/34800438
http://dx.doi.org/10.1016/j.jbc.2021.101426

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