Hypoxia-induced Fascin-1 upregulation is regulated by Akt/Rac1 axis and enhances malignant properties of liver cancer cells via mediating actin cytoskeleton rearrangement and Hippo/YAP activation

In solid tumors, hypoxia facilitates malignant progression of cancer cells by triggering epithelial-mesenchymal transition (EMT) and cancer stemness. Fascin-1, an actin-bundling protein, takes part in the formation of many actin-based cellular structures. In the present study, we explored the potent...

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Detalles Bibliográficos
Autores principales: Pu, Jian, Huang, Youguan, Fang, Quan, Wang, Jianchu, Li, Wenchuan, Xu, Zuoming, Wu, Xianjian, Lu, Yuan, Wei, Huamei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665929/
https://www.ncbi.nlm.nih.gov/pubmed/34897283
http://dx.doi.org/10.1038/s41420-021-00778-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665929/
https://www.ncbi.nlm.nih.gov/pubmed/34897283
http://dx.doi.org/10.1038/s41420-021-00778-5

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