Restoration of MiR-34a Expression by 5-Azacytidine Augments Alimta -Induced Cell Death in Non-Small Lung Cancer Cells by Downregulation of HMG B1, A2 and Bcl-2 Pathway

OBJECTIVE: Alimta (Pemetrexed) as an antifolate drug has been approved for the treatment of lung cancer. The aim of the present study was to investigate the combination effect of 5-Azacytidine (5-aza) and Alimta on the miR-34a and its target genes expression and induction of apoptotic cell death in...

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Detalles Bibliográficos
Autores principales: Amiri, Somayeh, Rabbani-Chadegani, Azra, Davoodi, Jamshid, Fakhrabadi, Hoda Gol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665979/
https://www.ncbi.nlm.nih.gov/pubmed/34939761
http://dx.doi.org/10.22074/cellj.2021.7332.

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665979/
https://www.ncbi.nlm.nih.gov/pubmed/34939761
http://dx.doi.org/10.22074/cellj.2021.7332.

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