Antibody–Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization

Antibody–drug conjugates (ADC) are a targeted cancer therapy that utilize the specificity of antibodies to deliver potent drugs selectively to tumors. Here we define the complex interaction among factors that dictate ADC efficacy in neuroblastoma by testing both a comprehensive panel of ADC payloads...

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Detalles Bibliográficos
Autores principales: Buongervino, Samantha, Lane, Maria V., Garrigan, Emily, Zhelev, Doncho V., Dimitrov, Dimiter S., Bosse, Kristopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666002/
https://www.ncbi.nlm.nih.gov/pubmed/34465595
http://dx.doi.org/10.1158/1535-7163.MCT-20-1034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666002/
https://www.ncbi.nlm.nih.gov/pubmed/34465595
http://dx.doi.org/10.1158/1535-7163.MCT-20-1034

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