A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model

BACKGROUND: Combining radiotherapy with PD1 blockade has had impressive antitumor effects in preclinical models of metastatic lung cancer, although anti-PD1 resistance remains problematic. Here, we report results from a triple-combination therapy in which NBTXR3, a clinically approved nanoparticle r...

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Detalles Bibliográficos
Autores principales: Hu, Yun, Paris, Sébastien, Barsoumian, Hampartsoum, Abana, Chike O., He, Kewen, Sezen, Duygu, Wasley, Mark, Masrorpour, Fatemeh, Chen, Dawei, Yang, Liangpeng, Dunn, Joe D., Gandhi, Saumil, Nguyen, Quynh-Nhu, Cortez, Maria Angelica, Welsh, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666086/
https://www.ncbi.nlm.nih.gov/pubmed/34895262
http://dx.doi.org/10.1186/s12951-021-01163-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666086/
https://www.ncbi.nlm.nih.gov/pubmed/34895262
http://dx.doi.org/10.1186/s12951-021-01163-1

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