Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics

Neurocryptococcosis, a meningoencephalitis caused by Cryptococcus spp, is treated with amphotericin B (AmB) combined with fluconazole. The integrity of the brain-blood barrier and the composition of the cerebrospinal fluid (CSF) may change due to infectious and/or inflammatory diseases such as neuro...

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Detalles Bibliográficos
Autores principales: Pippa, Leandro Francisco, Marques, Maria Paula, da Silva, Anna Christina Tojal, Vilar, Fernando Crivelenti, de Haes, Tissiana Marques, da Fonseca, Benedito Antônio Lopes, Martinez, Roberto, Coelho, Eduardo Barbosa, Wichert-Ana, Lauro, Lanchote, Vera Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666623/
https://www.ncbi.nlm.nih.gov/pubmed/34912784
http://dx.doi.org/10.3389/fchem.2021.782131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666623/
https://www.ncbi.nlm.nih.gov/pubmed/34912784
http://dx.doi.org/10.3389/fchem.2021.782131

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