Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy

Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell persistence. When using antigen-specific T cell receptors (TCR) instead of CARs, the lack of co-stimulatory signa...

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Detalles Bibliográficos
Autores principales: Olguín-Contreras, Luis Felipe, Mendler, Anna N., Popowicz, Grzegorz, Hu, Bin, Noessner, Elfriede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666660/
https://www.ncbi.nlm.nih.gov/pubmed/34912334
http://dx.doi.org/10.3389/fimmu.2021.750478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666660/
https://www.ncbi.nlm.nih.gov/pubmed/34912334
http://dx.doi.org/10.3389/fimmu.2021.750478

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