CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth. Herein, we identify a novel interaction partner of CD95, Kip1 ubiquitinat...

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Detalles Bibliográficos
Autores principales: Guégan, Jean-Philippe, Pollet, Justine, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Peter, Marcus E., Legembre, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666665/
https://www.ncbi.nlm.nih.gov/pubmed/34917906
http://dx.doi.org/10.1016/j.isci.2021.103538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666665/
https://www.ncbi.nlm.nih.gov/pubmed/34917906
http://dx.doi.org/10.1016/j.isci.2021.103538

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