Cargando…

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth. Herein, we identify a novel interaction partner of CD95, Kip1 ubiquitinat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guégan, Jean-Philippe, Pollet, Justine, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Peter, Marcus E., Legembre, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666665/ https://www.ncbi.nlm.nih.gov/pubmed/34917906 http://dx.doi.org/10.1016/j.isci.2021.103538

Ejemplares similares

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis
por: Gao, Yakun, et al.
Publicado: (1998)

CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
por: Qadir, Abdul S., et al.
Publicado: (2021)

CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases
por: Le Gallo, Matthieu, et al.
Publicado: (2017)

Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis
por: Bühling, Frank, et al.
Publicado: (2005)

Prognostic impact of apoptosis marker Fas (CD95) and its ligand (FasL) on bladder cancer in Egypt: study of the effect of schistosomiasis
por: Elmansy, HM, et al.
Publicado: (2012)

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
por: Henkler, Frank, et al.
Publicado: (2005)

CD95/Fas promotes tumour growth
por: Chen, Lina, et al.
Publicado: (2010)

Differential expression of Fas receptors (CD95) and Fas ligands (CD95L) in HIV infected and exposed uninfected children in Cameroon versus unexposed children
por: Dambaya, Béatrice, et al.
Publicado: (2019)

The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis
por: Fouqué, Amélie, et al.
Publicado: (2014)

The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis
por: Fouqué, Amélie, et al.
Publicado: (2020)

The Fas/FasL System in Reproduction: Survival and Apoptosis
por: Mor, Gil, et al.
Publicado: (2002)

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors
por: Galli, Gael, et al.
Publicado: (2022)

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens
por: Flores-Mendoza, Giovanna, et al.
Publicado: (2021)

Role of the Fas/FasL pathway in HIV or SIV disease
por: Poonia, Bhawna, et al.
Publicado: (2009)

CD95/Fas ligand mRNA is toxic to cells
por: Putzbach, Will, et al.
Publicado: (2018)

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L
por: Aragane, Yoshinori, et al.
Publicado: (1998)

Close Association between Fas Ligand (FasL; CD95L)‐positive Tumor‐associated Macrophages and Apoptotic Cancer Cells along Invasive Margin of Colorectal Carcinoma: A Proposal on Tumor‐Host Interactions
por: Sugita, Junichi, et al.
Publicado: (2002)

Involvement of Fas/FasL pathway in the murine model of atopic dermatitis
por: Bień, Karolina, et al.
Publicado: (2017)

Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation
por: Krzyzowska, Malgorzata, et al.
Publicado: (2021)

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation
por: Faletti, Laura, et al.
Publicado: (2018)

Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus
por: Vincent, Fabien B, et al.
Publicado: (2020)

Signaling through the Death Receptor CD95 (APO-1/FAS)
por: Peter, Marcus E.
Publicado: (2001)

Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma
por: Das, Satya N., et al.
Publicado: (2011)

CD70–CD27 ligation between neural stem cells and CD4(+) T cells induces Fas–FasL-mediated T-cell death
por: Lee, Eun Mi, et al.
Publicado: (2013)

Modulation of SIV and HIV DNA Vaccine Immunity by Fas-FasL Signaling
por: Yan, Jiabin, et al.
Publicado: (2015)

The signaling pathways by which the Fas/FasL system accelerates oocyte aging
por: Zhu, Jiang, et al.
Publicado: (2016)

Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance
por: Yamada, Akiko, et al.
Publicado: (2017)

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils
Publicado: (1996)

Enhancing Production and Cytotoxic Activity of Polymeric Soluble FasL-Based Chimeric Proteins by Concomitant Expression of Soluble FasL
por: Morello, Aurore, et al.
Publicado: (2013)

Plasma concentrations of soluble Fas receptors (Fas) and Fas ligands (FasL) in relation to CD4+ cell counts in HIV-1 positive and negative patients in Yaounde, Cameroon
por: Ikomey, George M, et al.
Publicado: (2012)

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment
por: Frazzette, Nicholas, et al.
Publicado: (2022)

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage
Publicado: (1995)

HSV-2 Regulates Monocyte Inflammatory Response via the Fas/FasL Pathway
por: Krzyzowska, Malgorzata, et al.
Publicado: (2013)

Genetic Polymorphisms of Fas/FasL Promoter Associated with Hepatitis C cirrhosis and HCC
por: Abed, Sally, et al.
Publicado: (2017)

Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis – Manipulation by the electromagnetic field
por: Szymanski, Lukasz, et al.
Publicado: (2018)

Elevated Concentrations of Soluble Fas and FasL in Multiple Sclerosis Patients with Antinuclear Antibodies
por: Sremec, Josip, et al.
Publicado: (2020)

Prognostic impact of FAS/CD95/APO-1 in urothelial cancers: decreased expression of Fas is associated with disease progression
por: Yamana, K, et al.
Publicado: (2005)

FasL Modulates Expression of Mmp2 in Osteoblasts
por: Svandova, Eva, et al.
Publicado: (2018)

Human FasL Gene Is a Target of β-Catenin/T-Cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions
por: Wu, Jianming, et al.
Publicado: (2011)

Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis
por: Tan, Siwei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_et66sha6r5c4sil8ne31nd893u