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Malonyl-acyl carrier protein decarboxylase activity promotes fatty acid and cell envelope biosynthesis in Proteobacteria

Bacterial fatty acid synthesis in Escherichia coli is initiated by the condensation of an acetyl-CoA with a malonyl-acyl carrier protein (ACP) by the β-ketoacyl-ACP synthase III enzyme, FabH. E. coli ΔfabH knockout strains are viable because of the yiiD gene that allows FabH-independent fatty acid s...

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Detalles Bibliográficos
Autores principales: Whaley, Sarah G., Radka, Christopher D., Subramanian, Chitra, Frank, Matthew W., Rock, Charles O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666670/
https://www.ncbi.nlm.nih.gov/pubmed/34801557
http://dx.doi.org/10.1016/j.jbc.2021.101434