Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease

ClpAP, an ATP-dependent protease consisting of ClpA, a double-ring hexameric unfoldase of the ATPases associated with diverse cellular activities superfamily, and the ClpP peptidase, degrades damaged and unneeded proteins to support cellular proteostasis. ClpA recognizes many protein substrates dire...

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Detalles Bibliográficos
Autores principales: Zuromski, Kristin L., Kim, Sora, Sauer, Robert T., Baker, Tania A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666677/
https://www.ncbi.nlm.nih.gov/pubmed/34780718
http://dx.doi.org/10.1016/j.jbc.2021.101407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666677/
https://www.ncbi.nlm.nih.gov/pubmed/34780718
http://dx.doi.org/10.1016/j.jbc.2021.101407

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