NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-T(EX)), which associated with prolo...

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Detalles Bibliográficos
Autores principales: Lewis, Emma L., Xu, Rong, Beltra, Jean-Christophe, Ngiow, Shin Foong, Cohen, Jordana, Telange, Rahul, Crane, Alexander, Sawinski, Deirdre, Wherry, E. John, Porrett, Paige M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666877/
https://www.ncbi.nlm.nih.gov/pubmed/34882194
http://dx.doi.org/10.1084/jem.20201599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666877/
https://www.ncbi.nlm.nih.gov/pubmed/34882194
http://dx.doi.org/10.1084/jem.20201599

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