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Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids

OBJECTIVES: To explore posttranslational modifications (PTMs), including proteolytic activation, multimerization, complex formation and citrullination of gelatinases, in particular of gelatinase B/MMP-9, and to detect in gelatin-Sepharose affinity-purified synovial fluids, the presence of specific M...

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Detalles Bibliográficos
Autores principales: Grillet, Bernard, Yu, Karen, Ugarte-Berzal, Estefania, Janssens, Rik, Pereira, Rafaela Vaz Sousa, Boon, Lise, Martens, Erik, Berghmans, Nele, Ronsse, Isabelle, Van Aelst, Ilse, Fiten, Pierre, Conings, René, Vandooren, Jennifer, Verschueren, Patrick, Van Damme, Jo, Proost, Paul, Opdenakker, Ghislain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667337/
https://www.ncbi.nlm.nih.gov/pubmed/34912337
http://dx.doi.org/10.3389/fimmu.2021.763832